Neurologic impairment in Wilson disease
نویسندگان
چکیده
منابع مشابه
Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease.
BACKGROUND AND PURPOSE Although previous brain imaging studies of Wilson disease (WD) focused on the dopaminergic system, correlational data on the integrity of the pre- and postsynaptic compartments are lacking. The present study was initiated to intra-individually determine the integrity of these compartments in patients with WD. METHODS A total of 46 patients with WD and 10 matched control...
متن کاملIs central pontine myelinolysis a sign of pre-symptomatic neurologic form of Wilson disease?
The diagnosis of Wilson disease (WD), a rare metabolic disorder, is based on clinical presentation of hepatic and/or neurologic involvement or routine screening due to the index case. Magnetic resonance imaging (MRI) was frequently normal in patients with hepatic form of WD (2). Central ponti-ne myelinolysis (CPM) is usually an acquired disorder associated with rapid correction of hypo-natremia...
متن کاملTreatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease.
OBJECTIVE To compare tetrathiomolybdate and trientine in treating patients with the neurologic presentation of Wilson disease for the frequency of neurologic worsening, adverse effects, and degree of neurologic recovery. DESIGN A randomized, double-blind, controlled, 2-arm study of 48 patients with the neurologic presentation of Wilson disease. Patients either received 500 mg of trientine hyd...
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Optical coherence tomography (OCT) has evolved dramatically since the first reports of this technology in 1991, and has become an integral part of the ophthalmology evaluation. In addition to providing an indispensible service for the retina physician, the ability to quantify the retinal nerve fiber layer has begun to change neuro-ophthalmic practice. In this regard, OCT has the potential to ch...
متن کاملThe child who has severe neurologic impairment.
The formulation of a diagnosis in a child who has neurologic impairment should not (except in extreme circumstances) be made on the basis of a single finding. For example, the presence of delayed milestones, primitive or exaggerated reflexes, abnormal muscle tone, abnormal posture, abnormal neurologic examination, and temporal course should all be used to make the diagnosis of cerebral palsy. F...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2019
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2019.02.43